导师简介: 王遥

　　个人简介：

　　王遥，2020年以“B类引进人才”受聘于我校，教授，博士生导师。于2023年入选北京市“科技新星”计划和中华中医药学会“青年人才托举工程”（A类）。

　　近年来，围绕固有免疫相关疾病的发病机制与中医药干预，以第一或通讯作者发表论文十余篇，包括Nature Cell Biology, Nature Communications 等，累积影响因子150分。相关成果被Nature, Nature Review Molecular Cell Biology, Immunity等重要刊物述评或引用500余次。作为项目负责人承担国家自然科学基金项目、省部级人才项目、校揭榜挂帅项目共7项，累计经费300余万元。

　　主要研究方向：

　　1.针对清热解毒中药的生物碱类、黄酮类药效成分开展系统研究，阐明相似化学结构的共性免疫调控和疾病治疗的免疫药理机制。

　　2.围绕固有免疫及相关疾病，通过细胞及动物疾病模型，利用最新的生化分子、细胞生物学及遗传学研究手段，揭示固有免疫调控新机制及免疫失调致病的学理。

　　科研成果：

　　1. Yao Wang*, Shaochun Yuan*, Xin Jia* , Yong Ge, Tao Ling, Meng Nie, Xihong Lan, Shangwu Chen, Anlong Xu^#. Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Nature Cell Biology. 21(11): 1346~1356. (2019) 中科院一区

　　

　　2. Xin Jia, Meiqi Zhang, Haojia Wang, Cuiqin Cheng, Qiqi Li, Lingdong Kong, Yiying Li, Xihong Lan, Shaochun Yuan, Yao Wang^#, Anlong Xu^#. ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function. Journal of Medical Virology. 95(3):e28637. (2023) IF：20.693

　　3. Tong Luo^*, Xin Jia^*, Wandi Feng^*, Jinyong Wang, Fang Xie, Lingdong Kong, Xuejiao Wang, Rui Lian, Xia Liu, Yingjie Chu, Yao Wang^#, Anlong Xu^#. Bergapten suppresses NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. Acta Pharmacologica Sinica. Sep;44(9):1867-1878. (2023)中科院一区

　　4. Meiqi Zhang^*, Xin Jia^*, Cuiqin Cheng, Haojia Wang, Lingdong Kong, Yiying Li, Qiqi Li, Fang Xie, Zhanhong Jia, Wandi Feng, Tong Luo, Yao Wang^#, Anlong Xu^#. Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection. Acta Pharmacologica Sinica. Nov;44(11):2253-2264. (2023)中科院一区

　　5. Haojia Wang*, Xin Jia*, Meiqi Zhang*, Cuiqin Cheng, Xue Liang, Xuejiao Wang, Fang Xie, Jinyong Wang, Yanli Yu, Yuting He, Qiutong Dong, Yao Wang^#, Anlong Xu^#. Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling. Jun:114:154786. (2023) Phytomedicine. 中科院一区

　　6. Xin Jia*, Shaochun Yuan*, Yao Wang*, Yonggui Fu, Yong Ge, Yutong Ge, Xihong Lan, Yuchao Feng, Feifei Qiu, Peiyi Li, Shangwu Chen, Anlong Xu^#. The role of alternative polyadenylation in the antiviral innate immune response. Nature Communications. 8:14605. (2017) 中科院一区

　　7. Wandi Feng*, Yao Wang*, Tong Luo, Xin Jia, Cuiqin Cheng, Haojia Wang, Meiqi Zhang, Qiqi Li, Xuejiao Wang, Yiying Li, Jinyong Wang, Guangrui Huang, Ting Wang, Anlong Xu^#. Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases. Acta Pharmacologica Sinica. Jun;44(6):1238-1251. (2022)中科院一区

　　8. Yao Wang*, Yi Liu*, Xiaoyu Zhang, Lihui Xu, Dongyun Ouyang, Kunpeng Liu, Hao Pan, Jian He, Xianhui He^#. Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K-Akt-mTOR pathways. International Immunopharmacology. 23:77~84. (2014) 中科院二区

　　9. Yao Wang*, Gaoxiang Zhao*, Lihui Xu, Kunpeng Liu, Hao Pan, Jian He, Jiye Cai, Dongyun Ouyang, Xianhui He^#. Cucurbitacin IIb Exhibits Anti-Inflammatory Activity through Modulating Multiple Cellular Behaviors of Mouse Lymphocytes. PLoS ONE. 9 (2): e89751. (2014) 中科院三区

　　10. Jian He*, Yao Wang*, Lihui Xu, Jing Qiao, Dong-yun Ouyang, Xianhui He^#. Cucurbitacin IIa induces caspase-3 dependent apoptosis and enhances autophagy in LPS-stimulated RAW 264.7. International Immunopharmacology. 16:27–34. (2013) 中科院二区

　　联系方式：

　　yaowang@bucm.edu.cn